Through 30 interviews with key donors, donor networks, and collaboratives in the United States (U.S.) as well as input from leaders at 15 key civil society and/or implementing organizations, the From Silos to Synergy report reveals a significant and encouraging shift in thinking about how funding decisions are made and where funding may be more effectively invested to advance progress on maternal and newborn health, rights, and birth justice issues. There is consensus that human rights and equity must be front and center in funders grantmaking approaches. While donors are notably in different stages of progress, almost all interviewees acknowledged the need to shift more funding to grassroots organizations led by local communities and to elevate the power of those communities to drive funding decisions. Many donors are struggling with how to operationalize these shifts from traditional, top-down grantmaking approaches to those that are more participatory and innovative. However, there are some promising models and trends among donors that are questioning the status quo. Key recommendations are outlined in the report, based on an analysis of the trends, gaps, and opportunities.